- Incidence and severity of medication-related osteonecrosis of the jaw in patients with osteoporosis using data from a Korean nationwide sample cohort in 2002 to 2019: a retrospective study
-
Su-Youn Ko, Tae-Yoon Hwang, Kiwook Baek, Chulyong Park
-
J Yeungnam Med Sci. 2024;41(1):39-44. Published online January 3, 2024
-
DOI: https://doi.org/10.12701/jyms.2023.01116
-
-
 Abstract
 PDF
- Background
Medication-related osteonecrosis of the jaw (MRONJ) is a significant concern, particularly among patients taking bisphosphonates (BPs), denosumab, and selective estrogen receptor modulators (SERMs) for osteoporosis. Despite the known risks, large-scale cohort studies examining the incidence and severity of MRONJ are lacking. We aimed to ascertain the incidence and risk of MRONJ among these patients, whom we stratified by age groups, medication types, and duration of use.
Methods
We utilized data from the National Health Insurance Service’s sample cohort database, focusing on patients aged 40 years and above diagnosed with osteoporosis. The patients were divided into three groups: those prescribed BPs only, those prescribed SERMs only, and those prescribed both.
Results
The overall incidence rate of MRONJ was 0.17%. A significantly higher incidence rate was observed among those taking osteoporosis medications, particularly among females with a relative risk of 4.99 (95% confidence interval, 3.21–7.74). The SERM group also had an incidence rate comparable to that of the BP group. Severity was assessed based on the invasiveness of the treatment methods, with 71.3% undergoing invasive treatment in the medication group.
Conclusion
This study provides valuable insights into the incidence and severity of MRONJ among a large cohort of patients with osteoporosis. It underscores the need for comprehensive guidance on MRONJ risks across different medication groups and sets the stage for future research focusing on specific populations and treatment outcomes.
- Reproductive toxic agents in work environments and related cases in Korea
-
Chulyong Park
-
Yeungnam Univ J Med. 2020;37(1):22-31. Published online January 9, 2020
-
DOI: https://doi.org/10.12701/yujm.2019.00416
-
-
8,587
View
-
90
Download
-
1
Crossref
-
Abstract
PDF
- There has been a growing concern and subsequent interest surrounding numerous reproductive toxic agents found in various working and non-working environments. Meanwhile, there have been many efforts in medical fields such as toxicology and epidemiology applying experimental studies to elucidate reproductive toxic agents’ characterization and health effects. However, there remains insufficient research data and inadequate evidence in humans. Adverse reproductive outcomes vary from transient, moderate health effects to severely detrimental consequences, such as permanent infertility or childhood cancer of one’s offspring. Furthermore, upon exposure to toxic agents, the latent period before reproductive health effects are observed is relatively short compared to other occupational diseases (e.g., occupational cancer); instant action is required once exposure to reproductive toxic agents is detected. Therefore, it is very important for workers and healthcare professionals to know about the reproductive toxic agents they are likely to be exposed to. In this review, we discuss the general epidemiology of reproductive health in Korea, and the information regarding these reproductive toxic agents.
-
Citations
Citations to this article as recorded by  - Association between Occupational Chemical Exposure and Sperm Parameters; A Narrative Review
Soheila Pourmasumi, Reza Vazirinejad, Zahra Ahmadi, Ali Mehdipour, Alireza Nazari
Journal of Occupational Health and Epidemiology.2023; 12(1): 50. CrossRef
|
E-Submission
Yeungnam University College of Medicine
